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Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII

2014 Study-reported magnitudes Representative figures from published research

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Additionally, mtDNA damage has been associated with PD etiology and progression (Tresse et al., 2023) and mitochondrial dysfunction is linked genetically to PD, since many mutations associated to familial cases of PD were found in genes such as PINK1 or PARKIN, which regulate mitochondrial turnover (Valente et al., 2004