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Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM

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In murine models of invasive mechanical ventilation simulating high mechanical stress, MUC5AC deletion was associated with increased survival, reduced neutrophil dysfunction, and dampened neutrophil production of inflammatory cytokines compared to wild type mice with the same ventilatory exposure [68]

10.1186/s40170-020-0209-8 168 RomanoA.MartelF

In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants

It works over a wide pH range and is used between 0.5-1.2%