The expression and activation of MMP-1, MMP-2, MMP-3, MMP-9 and/or MMP-13 are increased by oxidative stress, thereby reducing the collagens in the skin [82]
Treating the entire skin at once would lead to a very long recovery with high risk for infection and complication (think intense chemical peels and fully ablative laser therapy)
The repeated-dosing studies ran roughly one week, typically 4 to 7 injections
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