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In pediatric patients with congenital and acquired hypothyroidism, undertreatment may adversely affect cognitive development and linear growth, and overtreatment is associated with craniosynostosis and acceleration of bone age [see Use in Specific Populations (8.4)]

GLP-1s were initially used to treat diabetes, and the proposal would not affect anyone taking them for that purpose, only prescriptions for weight loss

Ardura-Fabregat A, Boddeke EW, Boza-Serrano A, Brioschi S, Castro-Gomez S, et al

Other studies have shown that changes in intestinal permeability occur before the onset of type 1 diabetes symptoms, and a change in TJ and dysbiosis associated specifically with a decrease in butyrate-producing bacteria have also been observed [1, 95]

3 Unidad de Neonatologa, Hospital Universitario Puerta del Mar, Cdiz

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