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During a 48-week phase 2 obesity trial, patients on weekly doses of Retatrutide (8 mg and 12 mg) had average body weight losses of 22.8% and 24.2%, respectively

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Mood Changes Increased irritability, low motivation, depressive symptoms, and a general sense of flatness

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Optimizing Tirzepatide Results Without Strict Fasting Tirzepatide's appetite-suppressing effects often deliver comparable weight-loss results to fasting without requiring extended hunger periods