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There were 99 (21.71%) patients reached the kidney progression events in total, 12 (10.53%) in group Q1, 11 (9.65%) in group Q2, 29 (25.44%) in group Q3, and 47 (41.23%) in group Q4 ( p 0.050)

Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system

10.3389/fphar.2022.842376 15 ChenH.TuckT.JiX.ZhouX.KellyG.CuerrierA.et al (2013)

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F-652 is a human IL-22 recombinant fusion protein composed of human interleukin 22 (IL-22) and human IgG2 Fc fragment, and its mechanism of action is similar to that of natural IL-22