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This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Clara et al., 2024

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Again, its main effect on cells of the monocyte/macrophages lineage is anti-inflammatory and pro-tolerogenic activity: first of all, in vitro studies on human monocytes or total PBMCs (peripheral blood mononuclear cells) evidenced a reduction in the production of proinflammatory cytokines (i.e

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