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This is stress response to rapid weight loss and caloric restriction, not direct medication effect

This effect is particularly noted with nasal spray use, which may be due to the higher dosages needed compared to subcutaneous injections [16]

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However, the role of placenta-specific NAD + depletion in the pathogenesis of PE and whether supplementation with an NAD + precursor will be an attractive preventative strategy for other PE subclasses are unknown

Do they wean off

This makes it a strong candidate for more neuroprotection research