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We found that 2A -adrenergic receptor activation by DA or NE results in G i1 recruitment to the receptor, with NE showing higher potency (EC 50 = 520 1.4 nM) and efficacy compared to DA (EC 50 = 2.1 0.002 M

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Atlas SJ, Kim K, Nhan E, et al

Semaglutide is a great example being used for helping type 2 diabetics lower their blood sugar, and then it got to, "Well, now let's help diabetics lose weight, because diabetics struggle with weight, the insulin resistance." Then it became, "Well, even if you're not a diabetic, could you benefit from losing weight?" Heck yes

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