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Furthermore, high-dose VitC strongly enhanced anti-cancer effects of immunosuppressor auranofin in the treatment of triple-negative breast cancer in vitro and in vivo [97]

The consequence of this role is that the ER is a net consumer of GSH and the GSSG has to be recycled by an unidentified mechanism

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GLUTATHIONE S -DERIVATIVES ACTIVATED BY GT AND PEPTIDASES Gamma-glutamyl transferase (EC2.3.2.2) catalyzes the transpeptidation and hydrolysis of the -glutamyl group of GSH and related compounds to an acceptor molecule, including water, amino acids, and peptides

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