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The compound's selectivity for NNMT over other methyltransferases is critical

GHK-Cu naturally exists in human blood plasma at concentrations of about 200 ng/mL at age 20, but drops to roughly 80 ng/mL by age 60

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Physicochemical considerations include solubility in aqueous buffers, sensitivity to oxidation (especially for cysteine- or methionine-containing peptides), and pH stability

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