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27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity

Early detection of PD was possible, with 82% sensitivity and 71% specificity, when using G Case activity, o- -Syn/t--Syn, and age jointly (Parnetti et al., 2014)

Many compounds that produce extraordinary results in preclinical models fail to replicate those outcomes in human clinical trials

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(Esitken et al., 2003), Klebsiella pneumoniae (Peakovi et al., 2013), Pantoea agglomerans (Xie et al., 2017), Azotobacter spp