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That distinguishes it mechanistically from single-pathway GLP-1 agonists such as semaglutide [7]

Adiposity changes at week 20 in the semaglutide arm accounted for 68% of the reduction in WC and 71% of the weight loss observed at week 104

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Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Andreeff M , Goodell MA, Heslop HE, Brenner MK

While these therapies reduce mortality and hospitalizations in HFrEF, their benefit in patients with heart failure with left ventricular ejection fraction (LVEF) 40% remains less conclusive

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