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They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

(109) conducted a meta-analysis of clinical trials

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Endocrine system regulation models

10.1016/s0140-6736(09)60659-0 14 CampbellJ