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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

Each level of appeal can add months or even years to the process, so its essential to act quickly and respond promptly to any communication from the SSA to help avoid unnecessary delays