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Moreover, Kla remodels immune cell functions (e.g., by activating genes like Arg1/PD-L1 and pathways like TGF-), inhibiting NKT cell activity to facilitate tumor immune evasion (109) ( Figure 2 )

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In this contest, AKT1 downregulation can lead to impaired mitochondrial dynamics, contributing to mitochondrial damage with a reduction of cell growth, as revealed both in our study and in other experimental conditions (Xie et al., 2022)