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Exendin-4, which shows 53% structural homology with GLP-1 (7-36), is as potent as endogenous GLP-1 in its insulinotropic effects via the mammalian GLP-1R

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Studies demonstrate that semaglutide primarily reduces fat mass while preserving muscle tissue, with approximately 65% of weight loss coming from fat reduction.[6] Recent clinical trials show that combining semaglutide with resistance training and adequate protein intake can preserve 50-80% of lean mass that might otherwise be lost during weight reduction

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