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The article also talks about why you have to follow the dosage schedule

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In addition, berberine can induce activation of PI3K/AKT signaling pathway, which is related to Nrf2 expression and neuroprotection (Zhang et al., 2017)

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Potential and Emerging Health Benefits Neuroprotection and Cognitive Enhancement: Research suggests methylene blue may support mitochondrial function, reduce oxidative stress, and potentially slow neurodegeneration