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The STRIDE trial also showed that semaglutide led to a greater estimated median ratio to baseline in maximum walking distance at week 52 than the placebo among people with symptomatic peripheral artery disease and T2D [14]

Finally, production of O 2 by both NOX2 and NOX4 also leads to the upregulation of VEGF 110,112

It inhibits vascular smooth muscle cell (VSMC) proliferation, platelet aggregation, and leukocyte adhesion (35)

Activating AR on lymphatic vessels improves the efficiency of lymphatic pumping by increasing the force of contraction (136)

Updated February 2026 | 10 min read If youve been following the conversation around GLP-1 and fat loss, you already know that drugs like Ozempic and Wegovy have completely reshaped the weight-loss landscape

Markers like ALT, eGFR, and lipase reveal organ stress before you feel symptoms