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GLP-1, GIP, exendin-4 and liraglutide had suppressive effects on oxLDL-induced foam cell formation, which is linked with the suppression of infiltrated macrophage foam cells in atherosclerotic plaques, resulting in repressed atherosclerotic plaque formation

Phase 3 trials are ongoing and retatrutide remains unapproved for routine clinical use

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Once reconstituted, retatrutide must be refrigerated at 36-46 degrees Fahrenheit (2-8 degrees Celsius)