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In view of these effects, a study was carried out using primary cultures of OFs from patients with GO and control subjects, which were treated with enalapril or with a control compound (lisinopril) ( Vitamin C, N-Acetyl-l-Cysteine, and Melatonin Additional antioxidant agents, namely Vitamin C, N-acetyl-l-cysteine and melatonin, were tested in another in vitro study performed in primary cultures of OFs from six GO patients and six control subjects ( 2 O 2 to induce oxidative stress, primary cultures were incubated with the various compounds

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PLoS ONE 6 , e28417 (2011)

This finding has implications for functional GI disorders, though it remains preclinical 10

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Spinraza-a rare disease success story