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5-Amino-1MQ Mechanism and Integration into the Stack 5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (a form of vitamin B3) and reduces NAD+ availability in cells

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Administered after status epilepticus, it promotes the restoration of glutamate metabolisms by normalizing seizure-induced inhibition of glutamine synthetase (GS), an enzyme that can reduce synaptic glutamate levels [172]

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