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The most common practical considerations are localized injection-site reactions and the need for correct technique and site rotation

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After being centrifuged at 12,000 g for 10 min, the total solubilized protein extract was yielded in the supernatant

Meyer, A

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Achieving sufficient drug concentration in the myocardium is difficult, as reactive oxygen scavengers tend to have short plasma half-lives and may not accumulate at injury sites [376]