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Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations

Key symptoms include: Fatigue: A pervasive sense of tiredness that does not improve with rest

After analysis of the expression pattern of immune checkpoints using ICP array, sEVs derived from activated tumor-associated effector T cells carry membrane-bound PD-1 (146)

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