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Biomarkers like baseline fasting glucose, HbA1c, and inflammatory markers also correlate with GLP-1 tolerability
Augmentation index normalized to 75 bpm (%) as the index of arterial stiffness, showed a tendency to decrease but unreached significance, together with the reduction of heart rate variability (HRV) and asymmetrical dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide (NO) synthesis, used for assessment of endothelial dysfunction (ED) [35]
, 4-5 (van Bommel, 2017), (), 2 , FDA
If medication is stopped without maintaining lifestyle changes, many people regain some of the lost weight
Common Side Effects Reported Across Phase 2 trials, participants experienced dose-dependent GI symptoms that are characteristic of GLP-1 receptor agonists: Nausea most frequent, especially during dose escalation Vomiting typically mild to moderate, subsiding with continued use Diarrhea and constipation fluctuating depending on individual tolerance Abdominal discomfort transient and often improved over time Dose-Response Relationship At lower doses (14 mg weekly), side effects were generally mild and manageable, though some participants still reported early GI symptoms
