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These studies suggest that despite the potential benefits of Lira, current evidence does not advocate the use of Lira in patients with NAFLD

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[4] The central nervous system is particularly vulnerable to the deleterious effects of oxidative stress, due to the high lipid content in the brain, so that an attack on membrane-lipids by ROS initiates a process of lipid peroxidation and subsequent oxidative modification of other cellular components

The HR shows some similarity to the characteristics of animal apoptosis, such as membrane dysfunction, vacuolization of the cytoplasm, chromatin condensation, and endonucleolytic cleavage of DNA (Iakimova et al., 2013)

Lozano-Bartolom J, Llaurad G, Portero-Otin M, Altuna-Coy A, Rojo-Martnez G, Vendrell J, et al

Repressor element 1-silencing transcription factor (REST) can regulate gene expression under hypoxia