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The most frequently reported AEs in all groups were gastrointestinal disorders, which are considered a class effect of GLP-1 receptor agonists

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This endotype perspective is critical for GLP-1RA use: if an individuals primary driver is IR and a lipotoxic background, the posterior probability of response to GLP-1RAs is theoretically higher

Some scientists hypothesize it could: Work synergistically with GLP-1 and GLP-2 Have unique metabolic or gut health effects Play a role in signaling pathways we dont yet understand For now, GLP-3 remains largely in the realm of basic research rather than practical therapeutic application