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AEs included increased serum creatinine (some cases managed by adjusting dose downward), hypertension (managed with anti-hypertensive meds), alopecia, cutaneous lymphoma, mouth ulcers, and acute gout (managed with allopurinol)

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This proliferative potential was hypothesized by the researchers to be coupled with a shift in the balance of apoptosis-related proteins

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We refer readers to the CY 2009 OPPS/ASC final rule with comment period (73 FR 68770 through 68771) for a discussion of this policy