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These drugs are expensive, coverage for their approved uses is already a running battle between payers and patients now that payers control ever more of the data and rules that gate access, and a further off-label indication for addiction lands in a system where coverage for behavioral health care is contested even for treatments that are approved and cheap

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Besides eGFR, additional variables associated with kidney function including plasma urea 29 , the uremic toxin p -cresol 30 or markers of kidney function decline (i.e., serum albumin 29 ), were among those affecting model outcomes the most

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