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The associated SNP, rs10305420, is a missense variant in the signal peptide of the GLP1R gene, changing the seventh amino acid from proline to leucine (p.Pro7Leu)

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In contrast, 14 states Alabama, Arizona, Delaware, Florida, Georgia, Kentucky, Louisiana, Mississippi, Montana, Nevada, South Carolina, Tennessee, Utah and Wyoming will need at least three times the number of practicing geriatricians in 2050 as there were in 2021 to care for those projected to have Alzheimer's dementia