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A personal or family history of medullary thyroid carcinoma (MTC) is an absolute contraindication because GLP-1 drugs may stimulate C-cell growth in the thyroid

Berberine may be worth considering for adults who: Are looking to support healthy blood sugar levels within the normal range Want to support weight management as part of a balanced diet and lifestyle Have been told they have pre-diabetes or insulin resistance and are exploring lifestyle and supplement support Are interested in supporting cardiovascular health through cholesterol and triglyceride management Are not suitable candidates for, or are waiting to access, prescription GLP-1 medications Important Considerations Berberine is a potent compound and is not without considerations: Drug interactions: Berberine can interact with medications including metformin, blood thinners, and certain antibiotics

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That might enhance insulin sensitivity when added to lifestyle interventions