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Crawford LJ, Walker B, Ovaa H, Chauhan D, Anderson KC, Morris TC et al
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Small molecule hydrophobic metabolites such as propionate, acetate, and butyrate can cross the epithelial barrier by simple diffusion along a concentration gradient from zones of elevated concentration in the intestinal lumen to places of diminished concentration in the epithelial cells (65)
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Conversely, excessive NADPH accumulation can induce reductive stress, leading to the upregulation of NADPH oxidase 4 through activation of the PI3K/Akt signaling pathway, thereby promoting ROS generation, as observed in osteoarthritis (96)
Arensman, M
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