These studies found that modest increases in resting heart rate did not translate to increased risk of heart attack, stroke, or other major cardiac events in patients without pre-existing heart disease
Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP
The duration of use varies for each individual
doi:10.1016/j.phrs.2022.106320
So theyve been doing it for many, many, many years
The strategy for these patients involves achieving target weight, stabilizing on a maintenance dose, then implementing a structured taper timed to allow the recommended washout period before conception