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not approved by the FDA, EMA or other agencies

Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes

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4.2.2 Gastrointestinal and hypertensive side effects of curcumin at high doses Although curcumin is best known for its anti-inflammatory and antioxidant properties, at high concentrations it can influence COX enzymes in a way that may lead to gastrointestinal or vascular side effects

fda.gov Sikiric P, et al