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High-level, it does three important things: Tells your pancreas to release insulin (which helps manage blood sugar ) Slows gastric emptying (which keeps you full longer) Sends a satiety signal to your brain that says youve had enough Now, medications like Ozempic and Wegovy are synthetic versions of GLP-1 at levels roughly 1,000 times higher than what a meal produces

Additionally, animal research shows that milk thistle extract increases the metformin maximum plasma concentration and area under the curve and decreases the renal clearance of metformin, due to inhibition of the multi-drug and toxin extrusion protein 1 (MATE1) renal tubular transport protein

When to Speak to Your Doctor or Prescriber Seek urgent medical attention for severe abdominal pain, persistent vomiting, or jaundice

The liver is responsible for the biotransformation of chemicals into less harmful forms, making them water-soluble, which makes it possible for the kidneys to excrete them afterward

When meal volume decreases, it becomes even more important to plan for: Adequate protein Nutrient-dense food choices Resistance exercise Strength and lean-tissue preservation A sustainable strategy for what happens next GLP-1 medications can be powerful tools

doi:10.3390/ijms20205002 16