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doi: 10.3389/fbioe.2025.1706245 Received 16 September 2025 Accepted 02 October 2025 Published 13 October 2025 Volume 13 - 2025 Edited by Luyun Cai, Bohai University, China Reviewed by Zhongxiang Li, Jinan University, China Zhanghui Chen, Central Peoples Hospital of Zhanjiang, China Updates Copyright 2025 Rana, Saifullah, Saeid, Kamal, Gao and Gao