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Cleavage of the disulfide bonds Due to the high reactivity of -SH group, thiols present in plasma occur mainly in forms of symmetrical and mixed disulfides

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This review discusses recent clinical and laboratory studies investigating the neuroprotective properties of metformin against DM-induced neurodegeneration and the roles of various molecular pathways, including mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and its related cascades

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