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Other clear candidates include patients with BMI 35+ who have tried and failed multiple structured weight loss approaches, patients with obesity plus severe sleep apnea, and patients with a metabolic syndrome phenotype where reducing insulin resistance matters

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Retatrutide acts on three hormone receptors GLP-1, GIP, and glucagon whereas Ozempic acts on GLP-1 alone

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Kasthuri S, Poongothai S, Anjana RM et al (2021) Comparison of glycemic excursion using flash continuous glucose monitoring in patients with type 2 diabetes mellitus before and after treatment with voglibose

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Real-world evidence (RWE) was a major contributor in uncovering some of these unexpected benefits

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