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Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA

Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts

This protective effect involves upregulation of antioxidant enzymes and maintenance of mitochondrial membrane potential, indicating Dihexa activates endogenous cellular defense mechanisms that guard against neuronal injury

68 And, a first-in-human open-label interventional study in 10 neonates showed that intranasal delivery of bone marrow-derived MSCs was safe and had no adverse side effects

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The GRK2 expression level may be a negatively regulating factor of EC activity according to the above study results