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B3 works by- Niacinamide inhibits the transfer of melanosomes (pigment-containing organelles) from melanocytes to keratinocytes, which helps reduce hyperpigmentation, including melasma

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Nature 462 , 745756 (2009)

By serving as a stable, bioactive ligand, the compound enables detailed mapping of binding affinities, receptor activation profiles, and subsequent intracellular events in various cell types

In simulation box, periodic boundary conditions were applied and ER protein or ER -DNA complexes centered in a cubic box (minimum 1.0 nm edge distance) with TIP3P water as solvent