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Individuals with Wilsons disease or other copper metabolism disorders, pregnant or breastfeeding women, and those with active malignancies or significant liver/kidney dysfunction should avoid this therapy

This approach reflects general CHB populations with heterogeneous drinking levels rather than alcohol-selected subgroups

All yeast strains used in this study ( Supplementary Table 7 ) were grown as previously described in Hartwells Complete (HC) medium containing 2% (w/v) glucose as carbon source [70] and lacking histidine for plasmid selection unless stated otherwise

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The infection by COVID-19 downregulates ACE2