Diet and exercise are helpful for sure, but human biology is strongly against most people at every turn
The addition of glucagon receptor agonism raises theoretical considerations around heart rate elevation , and Phase 2 data did show modest increases in resting heart rate in some participants a finding that will require careful monitoring in Phase 3 cardiovascular outcome trials
One user with 15-year patellar tendonitis reported dramatic initial improvement in the first two weeks, but then the progress drastically slowed despite experimenting with different doses and injection sites
Patients should also seek immediate medical attention for signs of gallbladder disease, including pain in the right upper abdomen, fever, or yellowing of the skin or eyes (jaundice)
Bedtime is preferred but consistency matters more than timing
Mounjaro starts at 2.5 mg weekly for four weeks, then moves to 5 mg