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In PIONEER 5 in patients with moderate renal impairment, and PIONEER 8 in patients receiving insulin, oral semaglutide was superior to placebo for reducing HbA 1c and body weight at week 26 [9, 11]

These revolutionary treatments, known for their effectiveness in aiding weight loss and improving overall health, have redefined how we approach obesity and metabolic health

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So here are some takeaways on the longevity of the obesity platform: Even without GLP-1 craze they grew the business (profitably?) to a $100M run-rate in 7 months with oral weight loss medications alone We will see a flood of new GLP-1 medications enter the market and the situation will move quickly and be fluid including the introduction of oral compounds that may lead to other use-cases for Hims There is some sort of precedent that compounding certain elements like end-dosage or side effect mitigation is considered clinically necessary and therefore defensible Hims & Hers will also offer brand-name GLP-1s on platform, maybe alluding to expectations of reduction in out of pocket cost over time, or an increase in supply My unsolicited thoughts for Hims would be to take advantage of this huge surge in cash and invest it into the sustainable, growing parts of the business

How It Works in Plain English Think of it this way: your body has signals that tell you when youre hungry and when youve had enough

Substance-induced mood disorder and bipolar depression were considered, too