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Neurology 32:13301334

Human spermatozoa and temperature: the elephant in the room

A post-hoc analysis of the CARES clinical trial was recently published, showing a reduction of CKD progression (a drop in GFR of 0.5 ml/min/year) in patients with gout treated with allopurinol or febuxostat who maintained a UA level of less than 6 mg/dL for a median of 2.5 years.50 These data could suggest that the deposits of monosodium urate crystals in the kidneys may be responsible for the progression of kidney disease

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In vitro, NAC improved ifosfamide benefits by decreasing nephrotoxicity without reducing antitumor effects (26)