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Institute of Medicine, 2021)

Oral pills carry minimal risk if nausea is mild, but if vomiting is frequent, alternative methods reduce uncertainty

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Using the popliteal lymph node assay, many drugs known to occasionally induce immune-mediated systemic side-effects in humans were shown to trigger significant reactions in mice and rats (Gleichmann, 1981

Regarding the form of vitamin B12 used, cyanocobalamin was the most common (n = 14), followed by methylcobalamin (n = 6), hydroxocobalamin (n = 4), and combinations including adenosylcobalamin in isolated cases

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