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High levels of leptin, which are common in individuals with obesity due to leptin resistance, fail to properly signal satiety, leading to continued food intake and reduced energy expenditure [32]

The hair loss was obvious in the temporal and occipital regions, and the local hair follicles in the scalp were red and swollen with oozed blood (see attached Fig

It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40

Can insulin-like growth factor-1 deficiency be involved in metabolic syndrome establishment