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Testosterone The principal androgen, testosterone, is an anabolic-androgenic steroid hormone which is synthesized from cholesterolproduced mainly in Leydig cells in men, and the ovary (25%) and adrenalzona fasciculata (25%) in women, via conversion from progesterone, with the remaining ~50% being produced from circulating androstenedione (Burger, 1 in healthy young men and 0.11.7 nmol.L 1 in healthy menstruating women under 40 y (Handelsman et al., 2018)

At this condition, body cannot detoxify itself over long periods and the ROS keeps on increasing continuously, leading to an oxidative stress condition

10) indicate a complex interaction between NFT derivatives and the Nrf2 pathway

(2004) Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult

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