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SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism

Rat-derived tendon fibroblast studies measured migration, survival and signalling endpoints

These experimental compounds work through various proposed mechanisms, such as stimulating melanocortin receptors in the brain, but lack robust clinical evidence and carry significant safety concerns

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Cancer cells have many strategies to stay alive, and Mcl-1 is an important factor for a lot of acute myeloid leukemias and lymphomas and some solid tissue cancers like breast cancers