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Lp(a) is linked to atherosclerosis (and therefore to the risk of heart attack and stroke) but unlike LDL cholesterol its also linked to aortic stenosis (narrowing of the main valve coming out of the heart)

In another trial of liraglutide treatment for adolescents aged 1217 years, 88.8% of treated adolescents experienced adverse events, with 64.8% reporting nausea, vomiting, or diarrhea (compared to 36.5% of adolescents in the placebo group, where 84.9% experienced adverse events) (35)

It can feel like a black box, but there is a process

Tirzepatide for weight loss demonstrated superior results in clinical trials compared to semaglutide-based medications

Women were more likely to have this outcome, with twice the risk of men

These matrices were then processed using the Seurat package for downstream analysis (36)