Evaluation of two independent cohorts of patients, who received 4g/day APAP for 12 weeks, revealed an association between CD44 rs1467558 polymorphism and elevated serum ALT levels, a biomarker of hepatocellular injury [106]
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In addition, the inner-mitochondrial-membrane enzyme dihydroorotate dehydrogenase (DHODH) transfers electrons derived from pyrimidine synthesis to ubiquinone, reducing it to ubiquinol and thereby suppressing ferroptosis in parallel with mitochondrial GPX4 (Mao et al., 2021)
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93 MimaA.OhshiroY.KitadaM.MatsumotoM.GeraldesP.LiC.et al (2011)
Ethics statement Human studies gained approval (ID 2023-KY-030-01) from the Medical Ethics Committee affiliated to Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital